Postdoctoral Research Associate, Genome Sciences

The Center for Public Health Genomics at the University of Virginia invites applications for a postdoctoral research associate position in the Onengut Lab.

This position is funded by an R01 grant from the NIDDK and focuses on investigating the role that T1D risk variants play in islet autoimmunity through advanced single-cell techniques. The lab seeks an independent, highly motivated PhD-level scientist with a strong background in single-cell genomic data biology and analysis to contribute to this important work.

The successful candidate will work on uncovering pathways that drive susceptibility to type 1 diabetes (T1D). The Onengut Lab integrates genetics, molecular biology, and bioinformatics to investigate how genomic loci linked to T1D contribute to disease mechanisms at the molecular level and within broader gene networks regulating islet autoimmunity. This project involves generating data from longitudinally collected human peripheral blood mononuclear cells at the single-cell level (CITE-seq) across individuals.

This is a unique opportunity for a motivated scientist to join the Onengut Lab in investigating autoimmune mechanisms in T1D through innovative genomic research.

Key Responsibilities:

• Implement computational approaches to analyze and integrate genomic data, inclduing whole genome sequencing, single-cell RNA-seq, and single-cell cell surface protein-seq (CITE-seq).

• Utilize an array of computational approaches to understand the role T1D risk variants play in the initiation and progression of autoimmunity.

• Collaborate with a multidisciplinary team to advance our understanding of autoimmune disorders.

• Communicate findings to the scientific community through conference presentations and publications.

Preferred Qualifications:

• PhD in Computational Biology, Bioinformatics, Genetics, or a related field, with a strong foundation in data analysis.

• Expertise in human biology, single-cell genomics, and computational biology to lead research efforts within this project.

• Experience with single-cell RNA-seq, CITE-seq, and/or multiome-sequencing data, along with genomic data integration.

• Interest in human genetics and autoimmune disorders.

• Solid background in both programming and biology.

• Strong communication skills and the ability to work both independently and collaboratively within a team.

Minimum Requirements:

Qualified candidates must have a PhD by the appointment start date.

This position will sponsor applicants for work visa who meet the qualifications.

This is a 12-month appointment with the possibility of renewal contingent upon satisfactory performance and the availability of funding. Salary is commensurate with education and experience.

This is an Exempt level, benefited position. For more information on the benefits at UVA, visit hr.virginia.edu/benefits

This position will remain open until filled. The University will perform background checks on all new hires prior to employment.A completed pre-employment health screen is required for this position prior to employment.

Physical Demands:

This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring finer finger manipulation.

To Apply:

Please apply through Careers at UVA , and search for R0066598.

Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs.'

Complete an application online with the following documents:

• CV

• Cover letter

• Contact information for 3 references.

Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Applications that do not contain all required documents will not receive full consideration.

For questions about the application process, please contact Yelena Markazyan, Academic Recruiter at ym3mm@virginia.edu

For more information about UVA and the Charlottesville community please see http://www.virginia.edu/life/charlottesville and https://embarkcva.com/

The University of Virginia, including the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician's Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex, pregnancy, sexual orientation, veteran or military status, and family medical or genetic information.