Scientist I, High Throughput Process Automation

Sarepta Therapeutics
United States, Ohio, Columbus
Mar 01, 2025
Why Sarepta? Why Now? The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. What Sarepta Offers At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas: Physical and Emotional Wellness Financial Wellness Support for Caregivers For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us The Importance of the Role The Early Research Process Development group is seeking a highly motivated and innovative scientist/engineer to lead the automation of high throughput process automation (HTPA) workflows within Sarepta's Process Development organization. Sarepta is enhancing its automation capabilities to accommodate its expanding pipeline, and this position will be pivotal in that effort. As a member of the HTPA team, this person will help drive the development of Sarepta's Gene Therapy programs and be responsible for automating downstream process development and analytical workflows to support early-stage production processes for the AAV vector research pipeline. The successful candidate will also participate in automation strategy and lead the implementation of HTPA laboratory automation projects, including analytical development, process development, and drug product formulation screening. The role will include development and continuous improvement of automated workflows including hands-on laboratory implementation and support, with the remainder of responsibilities involving working with vendors, stakeholders, and process development counterparts in a highly collaborative atmosphere. The ideal candidate would have experience with process development and laboratory automation, including working with robotic liquid handlers (e.g. Tecan, Hamilton, or Beckman), although candidates with more general experience in programming (Python, Excel VBA, Matlab, etc.) would also be considered. The Opportunity to Make a Difference Participate in automation strategy and oversee the implementation of a HTPD project portfolio Continuously improve established automation platforms and tools to improve efficiency Participate in the hands-on design and implementation of specific robotic systems according to defined end-user specifications, working with automation vendors and functional area stakeholders to develop automated workflows Support end-user automated workflows through training, method development, analysis, error recovery, equipment troubleshooting, and maintenance Develop and perform high throughput screening for optimization of downstream processes Identify and implement operational improvements and novel technologies to improve AAV downstream processes Participate in project related teams and other internal/external collaborations Maintain all appropriate laboratory records, author technical documents, protocols, and reports Perform routine data analysis and visualization for use in presentations, publications, and internal reports Contribute to a safe, efficient, and effective environment with personal accountability More about You Bachelor's degree in Biology, Biochemistry, Bioengineering, Computer Science, Mechanical Engineering, Chemical Engineering, Biomedical Engineering, or a related field is required BS with 5+ years, MS with 3+ years, or PhD with 0-2 years of relevant working experience, preferentially within established biotechnology/pharmaceutical organization in downstream process development is strongly desirable Experience in the development and maintenance of liquid handers and robotic systems with specific experience working with liquid automatic handling workstation (e.g. Tecan, Hamilton, or Beckman) is preferred, however candidates with more general programming experience will also be considered Successful design and implementation of high throughput process development workflows, including one or more of the following: chromatography screening, formulation screening, analytical high throughput screening, cell culture development, cell line development, and/or assay automation is preferred Prior experience with statistical analysis tools such as DoE is preferred Excellent written and verbal communication skills Proven record of successfully planning experiments and executing projects in collaboration with internal or external stakeholders Proven ability to work independently and effectively handle multiple priorities is a must Ability to maintain confidentiality of proprietary information expected What Now? We're always looking for solution-oriented, critical thinkers. So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply. #LI-Onsite #LI-TG1 This position requires work on site at one of Sarepta's facilities in the United States. The targeted salary range for this position is $95,200 - $119,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.