Principal Scientist, Discovery DMPK Bioanalytical

Are you looking to apply your mass spectrometry skills to solve challenging bioanalytical problems and help drive discovery programs forward, helping patients across the globe?

As a Discovery DMPK bioanalyst, you will be part of a team responsible for the analysis of molecules spanning GSK's portfolio. Using state of the art equipment, we work with compounds at stages from early discovery to development in a fast-paced discovery laboratory environment. In this role you will have opportunities to utilize, challenge, and expand your bioanalytical skill sets for small molecules, oligonucleotides, biologics, and other emerging modalities.

Responsibilities:

Working within the Discovery DMPK group, you will utilize your lab-bench technical knowledge and apply your experience in LC-MS approaches to support GSK's portfolio deliverables. In this role you will focus on the bioanalytical support of DMPK assays, exploratory biology experiments (e.g., PK-PD), and non-GLP toxicokinetic studies across modalities.

Within the team you will have the opportunity to gain broad experience while also taking deep scientific dives to support challenging analyses. Our evolving portfolio will require capability expansions across each aspect of bioanalytical workflows, including sample preparation, separations, analytical instrumentation, and data analysis. This role is positioned to help determine, drive, and deliver those improvements in parallel to provide our projects with the data they need for rapid design-make-test cycles.

Why you?
Basic Qualifications:

We are looking for professionals with these required skills to help us achieve our goals:

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 2+ years of relevant postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
• Strong understanding of DMPK principles and bioanalytical workflows; significant experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry
• Expertise in mass spectrometry-based analysis of small molecules in discovery settings
• Experience working in matrix teams to deliver complex studies by providing bioanalytical guidance into study protocols/designs and scheduling
• Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems

Preferred Qualifications:

• If you have the following characteristics, it would be a plus:
• Well-developed skillset in using and troubleshooting Sciex mass spectrometers
• Experience working within discovery and GLP bioanalysis settings; track record of applying study appropriate rigor to deliver data on time
• Previous bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities)

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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