Description & Requirements
We are seeking an exceptional and motivated Research Scientist to join the Martin-Rufino Group at the Lander Lab at the Broad Institute. In this position, you will lead the effort to build the first comprehensive functional maps of transcription factor activity, with the ultimate goal of fundamentally transforming hematopoietic stem cell transplantation as we know it. You will play a critical role in discovering the fundamental principles of transcription factor function and engineering new regulatory programs that enable minimally toxic transplants, directly shaping the future of cell therapies.
The successful candidate will develop new high-throughput technologies at the intersection of genetic perturbations, single-cell genomics, and epigenomic tools to uncover the complex regulatory mechanisms governing human cellular identity. You will also lead the translation of these foundational genomic insights into tangible, life-saving therapies, by engineering synthetic circuits into human cells and interrogating their effects. You will have direct access to the Broad's world-class technology platforms, enabling you to scale experiments at a throughput rarely possible in traditional academic settings. You will collaborate with a dynamic community of scientists and Platforms across the Broad Institute, including leaders in computational biology, genome engineering, and clinical research, to drive discoveries that define the next era of human genomics.
While optional, a cover letter is encouraged so we can better understand your journey, what drew you to our work, and why you feel this lab is the right next step for your career.
CHARACTERISTIC DUTIES
* Pioneer and lead independent research projects focused on developing large-scale technologies for mapping transcription factor activity, integrating genetic perturbations with single-cell epigenomic measurements
* Drive the translation of genomic insights into engineered circuits that redefine hematopoietic stem cell transplants
* Collaborate with scientists and postdoctoral fellows, and provide scientific leadership and mentorship to research associates to make fundamental discoveries in gene regulation and cell biology
* Make significant contributions to scientific papers, quantitative data analyses and presentations
* Contribute to generation of protocols and data analyses
* Work with multidisciplinary teams across the Institute and serve as a liaison between the lab and collaborators at the Broad to accelerate the clinical translation
REQUIREMENTS
* Ph.D. in Molecular Biology, Genetics, Biochemistry, or related life science field
* 0-5 years of relevant post-PhD laboratory experience in academia or industry
* Strong hands-on experience in high-throughput sequencing-based assays (particularly single-cell genomics, e.g. Perturb-seq, scATAC-seq, scRNA-seq, etc.), molecular biology (cloning, lentiviral preparation), flow cytometry and cell culture
* Experience with genome editing tools and their delivery, including CRISPR-based perturbation in human cells, viral-like particles, lipid-nano particles highly preferred
* Ability to design rigorous experiments and independently drive projects from hypothesis generation through publication
* Fluency in interpreting high-dimensional datasets and working closely with computational biologists to drive discovery
* Strong written and verbal communication skills, with the ability to clearly present complex data
* Ability to collaborate effectively in an interdisciplinary environment spanning experimental and computational biology
The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.
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Broad Institute
paid time off, paid holidays, 401(k), retirement plan
Mar 17, 2026