Director, Medical Affairs Strategy and Operations

The Director, US Medical Strategy and Excellence is a senior leadership role responsible for shaping and driving the strategic medical planning process across the U.S. TTR Medical Affairs organization. This role serves as a core member of the U.S. Medical Leadership Team and plays a critical role in ensuring strong alignment across U.S. Medical, Commercial, Global Medical Excellence, and Analytics and Insights (CC&I).

The Director will lead U.S. medical excellence initiatives, advance key medical capabilities, and design and execute pilots that elevate how Medical Affairs delivers evidence-based, patient-centric impact. This role requires both strategic vision and operational rigor, with accountability for end-to-end execution of priority initiatives.

Key Responsibilities

Medical Strategy and Planning

• Lead the U.S. Medical strategic planning process, including annual and multi-year medical plans aligned to brand strategy and enterprise priorities
• Translate global medical strategy into U.S.-specific plans that are actionable, measurable, and scalable
• Partner closely with U.S. Medical leadership to ensure strategic priorities are clearly defined, resourced, and executed

Medical Excellence and Capabilities

• Lead U.S. Medical Excellence, including the design, implementation, and continuous improvement of medical capabilities, processes, and ways of working
• Identify, pilot, and scale innovative approaches that enhance scientific exchange, insight generation, and medical impact
• Ensure alignment with Global Medical Excellence frameworks while tailoring execution to U.S. needs

Cross-Functional Alignment

• Serve as a key integrator across U.S. Medical, U.S. Commercial, Global Medical, and CC&I to ensure alignment on priorities, insights, and execution
• Partner with CC&I to operationalize analytics, dashboards, and insights that inform strategy, measure impact, and drive decision-making
• Ensure medical insights are systematically captured, synthesized, and shared to inform broader TTR strategy

Execution and Governance

• Own end-to-end execution of key U.S. Medical initiatives, from strategy through implementation and impact assessment
• Establish clear governance, milestones, and accountability to ensure consistent delivery of high-priority programs
• Monitor progress, identify risks, and course-correct as needed to ensure excellence in execution

Leadership and Influence

• Act as a core member of the U.S. Medical Leadership Team, contributing to enterprise-level thinking and decision-making
• Influence without authority across matrixed teams and stakeholders
• Model a culture of accountability, rigor, collaboration, and continuous improvement

Qualifications and Experience

Required

• Advanced degree required (PharmD, MD, PhD, or equivalent scientific degree)
• Significant experience in Medical Affairs with demonstrated leadership in strategy, planning, and execution
• Proven ability to operate effectively in complex, matrixed organizations
• Strong strategic thinking combined with operational discipline and follow-through

Preferred / Ideal Candidate Profile

• Experience spanning pharmaceutical, medical technology, and biotechnology organizations
• Prior experience in in-house Medical Director roles with accountability for medical strategy and execution
• Direct experience in Field Medical roles, including MSL positions, with strong understanding of scientific exchange and insight generation
• Experience leading Field Medical teams or Field Medical Excellence functions
• Demonstrated success partnering with commercial, global medical, and analytics teams
• Strong executive presence, communication skills, and ability to influence senior stakeholders

Core Competencies

• Strategic medical leadership
• Medical excellence and capability building
• Cross-functional integration and alignment
• Analytics-driven decision-making
• End-to-end execution and accountability
• Talent development and leadership influence

U.S. Pay Range

$208,300.00 - $281,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.